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Born in 19th century London, Sinister was one of the most brilliant scientists of his day. He entered a pact with the centuries-old mutant Apocalypse, who granted him immortality, among other powers.
The Red Skull, Johann Schmidt, was a former Nazi general officer and confidant of Adolf Hitler.
After his sister was wounded, Daniel was in contact with the medallion on his motorcycle later transforming him into the new Ghost Rider.